GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs9457247 | 1 | rs365189 | chr6:167384545 | RNASET2 | chr6:167343008-167412795:- | -0.23 | -4.95 | 1.14E-6 | Crohn's disease |
| BLCA | cis | rs3731714 | 1 | rs3731714 | chr2:202060820 | PPIL3 | chr2:201735680-201753999:- | 0.32 | 4.98 | 9.6E-7 | Trans fatty acid levels |
| BLCA | cis | rs6805251 | 1 | rs3732361 | chr3:119542297 | KTELC1 | chr3:119187785-119213552:+ | 0.24 | 4.33 | 1.91E-5 | HDL cholesterol |
| BLCA | cis | rs12045807 | 1 | rs3738483 | chr1:150801466 | HORMAD1 | chr1:150670542-150693352:- | 0.41 | 4.04 | 6.37E-5 | Congenital left-sided heart lesions |
| BLCA | cis | rs3738814 | 1 | rs3738814 | chr1:17331676 | MST1P9 | chr1:17081402-17090975:- | 0.33 | 6.73 | 6.37E-11 | Height |
| BLCA | cis | rs9309473 | 1 | rs3738848 | chr2:73761881 | ALMS1P | chr2:73872046-73912692:+ | 0.38 | 5.74 | 1.93E-8 | Metabolite levels |
| BLCA | cis | rs9783347 | 1 | rs3740711 | chr11:18379839 | GTF2H1 | chr11:18343816-18388590:+ | 0.29 | 5.51 | 6.75E-8 | Pancreatic cancer |
| BLCA | cis | rs8010715 | 1 | rs3742500 | chr14:24611978 | FAM158A | chr14:24608175-24610797:- | -0.42 | -8.32 | 1.53E-15 | IgG glycosylation |
| BLCA | cis | rs4803480 | 1 | rs3745937 | chr19:42071289 | CEACAM21 | chr19:42055886-42093196:+ | 0.34 | 7.76 | 7.88E-14 | Schizophrenia |
| BLCA | cis | rs17030613 | 1 | rs3748656 | chr1:113236681 | ST7L | chr1:113066142-113162405:- | 0.44 | 6.49 | 2.68E-10 | Diastolic blood pressure;Blood pressure |
| BLCA | cis | rs3751972 | 1 | rs3751972 | chr17:26206414 | C17orf108 | chr17:26205341-26220409:- | 0.24 | 4.71 | 3.41E-6 | Fractional exhaled nitric oxide (childhood) |
| BLCA | cis | rs798766 | 1 | rs3752749 | chr4:1737262 | FAM53A | chr4:1641609-1685854:- | -0.31 | -4.49 | 9.51E-6 | Urinary bladder cancer;Bladder cancer |
| BLCA | cis | rs1466788 | 1 | rs3754439 | chr1:110615094 | ALX3 | chr1:110602998-110613322:- | -0.21 | -3.89 | 0.000118 | Blood metabolite levels |
| BLCA | cis | rs1466788 | 1 | rs3754440 | chr1:110613674 | ALX3 | chr1:110602998-110613322:- | -0.22 | -4.06 | 5.97E-5 | Blood metabolite levels |
| BLCA | cis | rs7528684 | 1 | rs3761959 | chr1:157669278 | FCRL3 | chr1:157646278-157670775:- | 0.31 | 9.76 | 3.11E-20 | Type 1 diabetes autoantibodies |